This review explores the complex relationship between Alzheimer’s disease (AD) and osteoporosis, two conditions prevalent in aging populations that significantly impact quality of life. The article highlights shared mechanisms such as amyloid beta deposition, the Wnt/β-catenin signaling pathway, and estrogen deficiency, as well as mutual risk factors like age and fractures. Recent findings suggest a bidirectional relationship: AD increases the risk of fractures, while fractures early in life may elevate the risk of developing AD due to shared inflammatory and oxidative mechanisms. The review emphasizes the need for integrated therapeutic approaches targeting both conditions and calls for further research into the bone-brain connection and its implications for treatment and prevention in older adults.
To read the full article, click here: Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer’s Disease and Osteoporosis | Current Osteoporosis Reports

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By Hannah S. Wang, Sonali J. Karnik, Tyler J. Margetts, Lilian I. Plotkin, Alexandru Movila, Jill C. Fehrenbacher, Melissa A. Kacena & Adrian L. Oblak, January, 18th, 2024
Wang, H.S., Karnik, S.J., Margetts, T.J. et al. Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer’s Disease and Osteoporosis. Curr Osteoporos Rep 22, 483–494 (2024). https://doi.org/10.1007/s11914-023-00851-1