This article explores the sex-specific mechanisms underlying Alzheimer’s disease (AD), emphasizing the higher AD risk in women and the biological factors contributing to disease progression. It highlights the roles of sex hormones, sex chromosomes, and sex-specific differences in aging, inflammation, metabolism, and autophagy, supported by emerging technologies like single-cell RNA sequencing and multi-omics analyses. Addressing these differences is critical for developing precision medicine strategies and improving treatment outcomes for both men and women.

To read the full article, click here: Mechanisms of sex differences in Alzheimer’s disease: Neuron